Study of CCM Microvascular Endothelial Phenotype by an In Vitro Tubule Differentiation Model.

AUTHOR(S) Delle Monache S, Retta SF. Methods Mol Biol. 2020 ABSTRACT Cerebral cavernous malformation (CCM) proteins play critical roles for endothelial cell functions, including cytoskeletal remodeling, cell-cell interactions, cell polarity, tube formation, and angiogenesis. It has been shown that the…

Generation of CCM Phenotype by a Human Microvascular Endothelial Model

AUTHOR(S) Delle Monache S, Retta SF. Methods Mol Biol. 2020 ABSTRACT Cerebral cavernous malformations (CCMs) is a disorder of endothelial cells predominantly localized in the brain. Although a complete inactivation of each CCM protein has been found in the affected…

Adult Mesenchymal Stem Cells: Is There a Role for Purine Receptors in Their Osteogenic Differentiation?

AUTHOR(S) Carluccio M, Ziberi S, Zuccarini M, Giuliani P, Caciagli F, Di Iorio P, Ciccarelli R. Purinergic Signal. 2020 ABSTRACT The role played by mesenchymal stem cells (MSCs) in contributing to adult tissue homeostasis and damage repair thanks to their…

Upregulation of Epithelial-To-Mesenchymal Transition Markers and P2X7 Receptors Is Associated to Increased Invasiveness Caused by P2X7 Receptor Stimulation in Human Glioblastoma Stem Cells.

AUTHOR(S) Ziberi S, Zuccarini M, Carluccio M, Giuliani P, Ricci-Vitiani L, Pallini R, Caciagli F, Di Iorio P, Ciccarelli R. Cells 2019 Dec 29 ABSTRACT Glioblastoma (GBM) stem cells (GSCs), which contribute to GBM unfavorable prognosis, show high expression levels…